My husband was diagnosed in 1990 when I was pregnant with our first child. Fortunately, he was able to manage his symptoms for the next 14 years- but became seriously disabled in 2004. He passed away last year after suffering horrendous pain and feeling as if he was losing his identity. Humira "helped" but nothing made it beyond merely tolerable. One of his worst symptoms besides the pain was the GI issues. No doctor could explain why he had 20-25 episodes of diarrhea a day. My active, wonderful husband became enslaved to a toilet and a couch where he slept. He died in his sleep at the age of 57 which was the greatest blessing he could have- no hospital.