Does anyone understand and can explain the differences and benefits and risks in a simple way?
Humira is a TNF inhibitor, and Cosentyx is an IL-17 inhibitor.
From the Medications page of spondylitis.org:
"Both IL-17 and TNF-α are inflammatory cytokines (cell signaling molecules) that, as the name implies, signal to activate inflammation throughout the body, modulating or altering the immune system response. Inflammatory cytokines play an important role; however, when there is an overabundance of these, as has been described in inflammatory disease, they can cause harm to the body if left unchecked.
IL-17 and TNF-α cytokines signal to specific immune cells directing them to activate inflammation, with each cytokine being responsible for signaling to a different set of cells. IL-17 and TNF inhibitor medications work by targeting their respective cytokines, obstructing their signaling pathways, and by this mechanism seek to reduce inflammation. Since secukinumab* targets different cytokines than the TNF inhibitors, the hope is that this newer biologic medication will help those who haven’t responded well to the TNF inhibitors, or are not able to tolerate them.
Cosentyx carries similar risks of infections, and reduced ability to fight infections as the TNF inhibitors. It has also shown in clinical trials to exasperate inflammatory bowel disease in patients who have it, as well as bring on new cases of inflammatory bowel disease. "*secukinumab is the generic name for Consentyx
Link to the Medications page: https://www.spondylitis.org/Medications