Hello: first time here. I am 45 yo female with AS, just diagnosed in the last year. I started Humira and was on it for 3 months without any big noticeable difference, maybe 50% less pain when at rest. I developed a rash on the back of my neck and had sinus pain and pressure and some abdominal pain. I switched rheumatologists a few months later and restared it. Same results and same side effects. However, now I've noticed much more pain. Calf pain that won't go away. A lot of muscle pain and fatigue. Cold hands and feet. Left wrist pain and two of my fingers on left hand feel numb and difficult to move at times. Insomnia, restless legs. The only other drug I started was Sulfasalazine, at the same time I restarted the Humira. I feel so crappy, but don't know if it's the disease, the side effects, the drug not working ????? Just seeing if anyone else has any insight. Thanks!