I tried Cosentyx for about three months- I had breakthrough iritis while on it, but also diarrhea for about three days after each injection. I just felt bloated and gross. I'm allergic to all nsaids, have used and eventually lost efficacy on humira, Enbrel, Simponi (my favorite), then had a big reaction to Cimzia. I am now on Remicade after my brief stint on Cosentyx. I would ask for Simponi because the injections are easy, painfree, monthly, and it worked great for about three years.