... Extreme fatigue, fogginess. The best I can describe is that feeling of after you wake up from general anesthesia. The difference with consentyx was that it made me feel that way from day 1. Has anyone else had similar experiences and failures with biologics? Its just hard to keep on pushing when you've literally been sick for 18 months and continue to see every option fail.
Same here. On Humira weekly for 12+ years: Initially helpful. But during the last few years, overwhelming fatigue like if you've taken a sleeping pill & brain fog like being anesthetized. Zero energy and difficulty thinking and talking - just like being immediately post-op. Pain was strong w/ constant headaches and intestinal pain and needed Oxy & Percs to be able to get out of bed. And constant UTI's. Could eat only bland food due to gut pain. Ultimately poor quality of life for past few years.
Went off the Humira 3 months ago and 'woke up'. Lots more energy, brain fog lifted - felt great! better than I had in years. Pain was mild and even had some pain free days! no more UTI's --- until a month ago, then the pain became totally unbearable. Unable to walk - barely able to get to the bathroom, then back to bed. Blinding headaches. Pain meds didn't help much at all. Zero quality of life.
Doc put me on Simponi - took first shot today. Fingers crossed that it works, because this disease has me at the end of my rope.
I have AS w/ Crohns so very few treatment options. Can't take any anti-inflammatories, and few biologics treat both. Tried 1 infusion of Remicade 13 years ago - it did nothing helpful --- but dropped my already low blood pressure extremely low and made my heart pound.
I'm thrilled and hopeful for all sufferers who've gotten relief from their treatment plan. I wish I could join them with my own success story.
Hang in there *awesomeman*, hope the Simponi will work out for you and me. Something has to work sooner or later. There's new stuff coming down the pipeline regularly and everyone reacts differently re effectiveness and side effects. Best of luck to us all.
AS w/ Crohns - diagnosed 2005 - HLA b27 Negative.
Back pain since childhood: 1970s. Cousin has AS. Mother died from AS complications.
Just started Simponi. On Humira weekly for 12 years.