For some people it takes a fairly high dose of prednisone before they feel it's helping. My rheumy once prescribed a 5 day course of prednisone at 25mg per day when I complained of sore SI joints. It did nothing. I've taken a few Medrol dose paks over the years for various issues and they helped the issue for which they were prescribed but did nothing for my joints.
Ginny - 58 year old female
Dx with USpA in March 2013; changed to AS in July 2015
Iritis and Scleritis
unicompartmental knee replacements: right-June 2014, left-Aug 2018
MTX, Humira, Cyclobenzaprine, plus Celebrex as needed
Supplements: Folic Acid, Vitamin A, Vitamin D, Calcium, Fish Oil, Culturelle probiotic, Melatonin (as needed)