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Re: Methotrexate: please share your experience [Re: seymour] #281596
10/02/18 11:38 PM
10/02/18 11:38 PM
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seymour Offline OP
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Thanks Ginny.

I was under the impression that you can't produce antibodies to Enbrel.

Re: Methotrexate: please share your experience [Re: seymour] #281600
10/03/18 02:09 AM
10/03/18 02:09 AM
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SouthernMoss Offline
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I think that's probably true, or at least you're less likely with Enbrel.


Ginny - 57 year old female
Dx with USpA in March 2013; changed to AS in July 2015
Iritis and Scleritis
unicompartmental knee replacements: right-June 2014, left-Aug 2018
MTX, Humira, Cyclobenzaprine, plus Celebrex as needed
Supplements: Folic Acid, Vitamin A, Vitamin D, Calcium, Fish Oil, Culturelle probiotic, Melatonin (as needed)
Re: Methotrexate: please share your experience [Re: seymour] #281602
10/03/18 02:14 AM
10/03/18 02:14 AM
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seymour Offline OP
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So that would make adding MTX totally useless in my case, I guess.

I do have pain in my shoulders, ribs and toes though.

Last edited by seymour; 10/03/18 02:14 AM.
Re: Methotrexate: please share your experience [Re: seymour] #281604
10/03/18 02:20 AM
10/03/18 02:20 AM
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SouthernMoss Offline
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Yes, unless MTX provides some kind of synergistic effect with the Enbrel, which is probably what you've been trying to research. But if MTX did help your peripheral symptoms, it might make your spinal symptoms easier to deal with, since you wouldn't be dealing with pain in so many different locations.

Last edited by SouthernMoss; 10/03/18 02:22 AM.

Ginny - 57 year old female
Dx with USpA in March 2013; changed to AS in July 2015
Iritis and Scleritis
unicompartmental knee replacements: right-June 2014, left-Aug 2018
MTX, Humira, Cyclobenzaprine, plus Celebrex as needed
Supplements: Folic Acid, Vitamin A, Vitamin D, Calcium, Fish Oil, Culturelle probiotic, Melatonin (as needed)
Re: Methotrexate: please share your experience [Re: SouthernMoss] #281605
10/03/18 02:43 AM
10/03/18 02:43 AM
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seymour Offline OP
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Originally Posted by SouthernMoss
Yes, unless MTX provides some kind of synergistic effect with the Enbrel, which is probably what you've been trying to research. But if MTX did help your peripheral symptoms, it might make your spinal symptoms easier to deal with, since you wouldn't be dealing with pain in so many different locations.


I agree completely!

I'm just unsure if MTX works for stuff like shoulders or ribs.

Re: Methotrexate: please share your experience [Re: seymour] #281718
10/10/18 02:14 AM
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I haven't taken MTX but I started sulfasalazine about 9 months ago (it's similar to MTX - not a biologic and mainly for peripheral symptoms). My rheumatologist said that some patients find it helpful for axial symptoms as well and that has definitely been the case for me.

It has helped way more with the peripheral symptoms but I have noticed some small but consistent and meaningful benefit for some longstanding neck and rib issues.

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