Previous Thread
Next Thread
Print Thread
Identical twins light the way for new genetic caus #282501
01/24/19 08:55 PM
01/24/19 08:55 PM
Joined: Mar 2016
Posts: 561
S
sdot Offline OP
Registered Visitor
sdot  Offline OP
Registered Visitor
S

Joined: Mar 2016
Posts: 561
Identical twin toddlers who presented with severe arthritis helped scientists to identify the first gene mutation that can single-handedly cause a juvenile form of this inflammatory joint disease. By investigating the DNA of individual blood cells of both children and then modelling the genetic defect in a mouse model, the research team was able to unravel the disease mechanism.

https://www.sciencedaily.com/releases/2019/01/190124141644.htm

Re: Identical twins light the way for new genetic caus [Re: sdot] #282502
01/24/19 10:35 PM
01/24/19 10:35 PM
Joined: Mar 2013
Posts: 2,091
MS
S
SouthernMoss Offline
Registered Visitor
SouthernMoss  Offline
Registered Visitor
S

Joined: Mar 2013
Posts: 2,091
MS
Interesting article.


Ginny - 58 year old female
Dx with USpA in March 2013; changed to AS in July 2015
Iritis and Scleritis, both currently in remission
unicompartmental knee replacements: right-June 2014, left-Aug 2018
MTX, Humira, Cyclobenzaprine, plus Celebrex as needed
Supplements: Folic Acid, Vitamin A, Vitamin D, Calcium, Fish Oil, Culturelle probiotic, Melatonin (as needed)
Re: Identical twins light the way for new genetic caus [Re: sdot] #282510
01/29/19 05:43 PM
01/29/19 05:43 PM
Joined: Aug 2017
Posts: 89
K
kglenn Offline
Registered Visitor
kglenn  Offline
Registered Visitor
K

Joined: Aug 2017
Posts: 89
Interesting!

I am an identical twin, so naturally my sister has been following my medical progression with great interest. So far, I have developed scleroderma with secondary Sjogren's and spondylitis. She also has symptoms of Sjogren's and antibodies for both RA and Lupus, but no significant symptoms of either and no spondylitis (so far).

I did find it amusing that the 'toddlers' in the article were quoted as saying "We are delighted to know that an explanation has been found for our illness and more so because we are sure it will help other children." Clearly the arthritis hasn't slowed down their cognition. LOL!


Karen
Female, early 50's, HLA B27+, family history of SpA
Diagnoses: USpA (9/17), limited Scleroderma/Raynaud's phenomenon/Sjogren's syndrome (1/16), stroke (8/15), Factor V Leiden (8/15)
AS symptoms: right heel enthesitis/tendonitis; elbow tendonitis; mild low back/buttocks and hip pain/stiffness; normal MRI
Treatment: Xarelto; vitamins D3, B12, folate Primary non-responder to Enbrel and Cosentyx
Re: Identical twins light the way for new genetic caus [Re: sdot] #282511
01/29/19 06:57 PM
01/29/19 06:57 PM
Joined: Apr 2018
Posts: 100
A
achala Offline
Registered Visitor
achala  Offline
Registered Visitor
A

Joined: Apr 2018
Posts: 100
sounds like Bruce Willis again... remake of Look Who is Talking (1989)?

Last edited by achala; 01/29/19 06:59 PM.

diagnosed with AS April 2018, starting with cervical pain/stiffness; Aug 2018 enthesitis/bursitis left Achilles
diagnosed with iridociclitis Nov 2017 (4 flares so far) - bilterally DES,PVD
Eosinophilic Gastritis
Signs of inflammations/erosions on MRI`s for axial and Achilles/calcaneus + bursitis
Naproxen (occasionally), Sulfasalazine 3000 mg per day
Supplements: vit A&D, reishi mushrooms, fish oil/probiotic/ Mediterranean NSD
plenty of swimming

Moderated by  ElinAslanyan, RyanMiyamoto 

Powered by UBB.threads™ PHP Forum Software 7.6.2