i have seen several people on past topics/posts say this and i am wondering if that is a fact, or maybe just opinion based on how they feel their body responded to it. (which as we all know could vary quite a bit, so how to know if MTX was the reason)

because if MTX is a DMARD, how would it know to 'only' target peripheral areas instead of the spine? wouldn't it just target all joints?

just wondering if anyone else knows this. my Rheumy has me on both MTX and Humira, but did not say that one was for peripheral and the other axial...


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Female / 43 yrs old
~ Pain started in 2000
~ dx w/Cervical Myofascial Pain Syndrome in 2003
~ dx change to USpA/AS in Feb 2015 (HLA-B27 negative)
Currently taking Gabapentin 300mg/nightly, Meloxicam 15mg/daily, MTX 7.5mg/weekly, Folic Acid 3mg/daily, Biotin 5000mg/daily, and Flexiril & Norco only when absolutely needed.
tried Humira--no success, Enbrel & Cimzia--severe allergic reactions.
started Simponi infusions Jan 2016.