rivercanoeist - thanks for sharing your experience on this!
- to your questions:
1) do you feel normal when you take them?
yes - I don't feel so different with or without them except if I go without them for a while I feel low level pain/inflamation around the SI joint area. I will try to cut them down although I'm actually finding the trend is to be taking more. First few bottles I could make a month's supply (15mg/d) last for 6-7 weeks where the latest was closer to 5 weeks. (I'm about 8-9 months since DX)
2) if you find that you can skip a couple of days of taking one stay on them
I've forgotten for a couple days and restarted without much consequence but if I cut to 1/2 dose for more than a week I start to feel stuff - at least that was true last time I did it - not so sure this thing is really so predictable all the time - once I let it get to the point of feeling something it seems like it will keep progressing and knock me off the running for a few days and add a little limping to my walking from SI joint area pains before I can get the upped dosages to take away the inflamation again so I've been a little leary chopping down very quickly.
So I guess with those responses you'd suggest I stick with the NSAIDs. I'm not so afraid of biologics but they have their drawbacks for an endurance athlete too for example my immunity system takes a pretty big hit with each big event or even big workout and I have to take special care to not get sick - sometime I take airborne for example to be premptive. I would be double prone with the biologics. I'm kinda wondering if I can do a switch back and forth kinda thing using one or the other depending somewhat on what I'm doing - I was going to talk to my Rhuemy about the pros/cons of this idea.
I'll take a look into the proton pump inhibitor option. I've wondered about Ulsers and if they are permanent or not - could it be after I get one after perhaps a few years of NSAIDs I could switch to the biologicals and it would heal back up again or is it more like once you get em your stuck with them forever.
fwiw - I did find what appears to be a pretty good study showing what changes with NSAIDs at anti-inflamitory dosages during Exersize (rofecoxib - a COX-2 inhibitor - I presume a reasonable approximation to Meloxicam which I take).Link
Main take away's I got:
- Never volenteer for a test like this (I just don't even want to go there with rectal temps while running/cycling).
- NSAIDs reduce how much body temperature increases from exersize similar to how taking them for a fever will reduce the fever.
- sweatrate is no different w or w/o NSAIDS - this gives me some reassurance that NSAIDs don't actually cause
dehydration - rather it seems more the issues are the risk-factors while
dehydrated - so the message is don't get dehydrated.
- heartrate was on average 6 bpm lower with NSAIDs - as I uses heartrate in my training this was interesting for me and actually matches up pretty well with how my training heartrate zones have changed with the NSAIDs (maxHR at the end of a 5k race with NSAIDs was 176 where last year without NSAIDs at a similar fitness and race weather it was 182).