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Remicade Adjustment
#255519 07/24/13 01:19 PM
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I will be having my infusion on Aug. 1, (this will be my 5th treatment)I think I need to have my infusion sooner. Has anyone else had this happen? My schedule is for every eight weeks. It has been six week and I think the Remicade stopped working. Fatigue, SI soreness other symptoms have reoccured.

Re: Remicade Adjustment
StLouis #255525 07/24/13 02:09 PM
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The original interval years ago was eight weeks. Remicade is now recommended every six weeks by the manufacturer Centocor. I found that at about 7 weeks the symptoms came back. Sometimes at eight weeks I am ok. Sometimes at five weeks I am already wanting it. Not sure what it depends upon.


Diagnosed 2001 after years of joint pain. Remicade started 2002 - 5mg/kg every 7 weeks.
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Re: Remicade Adjustment
WhiteCell #255529 07/24/13 02:45 PM
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Originally Posted By: WhiteCell
Remicade is now recommended every six weeks by the manufacturer Centocor.

Clarification: this recommended interval is for AS, not for all conditions for which Remicade is FDA-approved.

Definitely keep a symptom log and bring this up to your doctor!


Jen, 42, happy partner of James and Moma to Evan, 14, & Lucy, 12.5 (Crohn's dx @ age 3; on Remicade since April 2010.) I take piroxicam, Flexeril, & Nucynta ER nightly. 3 anti-TNFs didn't pan out for me.

"Science is the father of knowledge, but opinion breeds ignorance." -- Hippocrates
Re: Remicade Adjustment
StLouis #255530 07/24/13 02:46 PM
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Yes, call your dr. Do not wait, it can be very very depressing to feel the disease come back. Plus, after a while the impact will diminish because it has to ramp up to work again.

Before I switched meds, I was getting Remicade every 4 weeks. But like Whitecell says it is recommended every 6 weeks for AS.

Anna


Actema IV once a month (with pre loading for allergic reaction), Cymbalta x1 daily, Arava 20mg daily. Diagnosed with AS in 2004, suffered undiagnosed since 1982.
Re: Remicade Adjustment
StLouis #255534 07/24/13 03:21 PM
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I sent an email to the doctor and he just followed it up with a phone call within ten minutes (he is awesome). He is going to increase the dosage of Remicade and will put me back on predisone for one week. He thinks the Remicade wore out. If this next process doesn't work, he will do the infusions every six weeks.

Re: Remicade Adjustment
StLouis #255535 07/24/13 03:21 PM
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Thanks for the responses--it always helps to get the feedback and suggestions.

Re: Remicade Adjustment
StLouis #255536 07/24/13 03:25 PM
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Interesting approach - usually in this kind of situation the first change would be to reduce the time between infusions (esp. since it does work, and the recommendation is shorter than what you are currently doing.) Glad he is so on-the-ball - you are lucky there!

My daughter was on Remicade a little over a year when it started to lose effectiveness. The doc did blood tests to see if she was developing antibodies to it and since she wasn't, he doubled the dose from 5 mg/kg to 10 mg/kg. That did the trick and has been working for about 2 years now, I guess!

I hope this works for you, too!

Re: Remicade Adjustment
StLouis #255540 07/24/13 03:54 PM
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At this point, he might not be able to get an earlier infusion appointment, it can be tough in the summer.

Pred is a great bridge and helps reduce inflammation so that your body will accept the remicade. I often get back on pred with med changes, increase.

Hope you feel better soon,

Anna


Actema IV once a month (with pre loading for allergic reaction), Cymbalta x1 daily, Arava 20mg daily. Diagnosed with AS in 2004, suffered undiagnosed since 1982.
Re: Remicade Adjustment
Banana #255543 07/24/13 04:57 PM
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Originally Posted By: Banana
Pred ... helps reduce inflammation so that your body will accept the remicade.

Anna, I have not heard anything like this before. Can you elaborate/explain more?


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