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Study: Extend TNFi Evaluation Period in AS to 6 mo
#273463 03/04/16 02:12 PM
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http://www.medpagetoday.com/Rheumatology/Arthritis/56490
Study: Extend TNFi Evaluation Period in AS to 6 months

Found this one. I always search NEWS sections for AS(hoping there is a cure being developed somewhere) and in the process usually end up finding some other useful things.

Regards


Male, early 30s. AS diagnosed Sep 2015. HLAB27+
Current medicines: Omeprazole, Vit D3, Celecoxib(1 tab)/Zorvolex(2 tabs)(alternatimg between these two every week), Pyridoxine, Isoniazid, MTX(3 tab) every wednesday, on humira every two weeks since Dec 2015, Weekly Humira since June 18th 2016
On cosentyx 300mg a month since Dec '16
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273466 03/04/16 08:06 PM
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Wow - great info!


Arthritis issues since youth, back pains started at age 14 (1994). Dx with AS in January, 2016.
HLA-B27 Positive
Other Dx: GERD, Raynauds, Bursitis in Mutiple Joints
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273470 03/05/16 04:33 PM
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Poor people should wait 6 months to see if it works? Not such good news. Usually for me though they worked quickly.


Actema IV once a month (with pre loading for allergic reaction), Cymbalta x1 daily, Arava 20mg daily. Diagnosed with AS in 2004, suffered undiagnosed since 1982.
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273563 03/11/16 05:44 PM
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@EmA_LI_80
I think so too. I think it is more of because they(insurance) do not want to change the medications often, as these are very costly. They want to shift the burden on patient to completely exhaust the possibility of medication getting into action at longer periods.


Male, early 30s. AS diagnosed Sep 2015. HLAB27+
Current medicines: Omeprazole, Vit D3, Celecoxib(1 tab)/Zorvolex(2 tabs)(alternatimg between these two every week), Pyridoxine, Isoniazid, MTX(3 tab) every wednesday, on humira every two weeks since Dec 2015, Weekly Humira since June 18th 2016
On cosentyx 300mg a month since Dec '16
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273564 03/11/16 08:57 PM
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Shipping news,

I am all ears to new information in regards to fuorwarding therapy for those of us with these terrible diseases, AS and spondyloarthritis, and appreciate your post.

For me, this is the very first time I have heard of any researchers looking at a patients BMI (body mass index - a calculation looking for a comparison of body fat cells an individual has. The calculation factors in height and weight for adults to reach a BMI percentage) to foretell an individual's response to these type medications, anti-TNF. In other words, this is one more tool for your rheumatologist to utilize in choosing this medication for you as the rheumatologist, per this article, may be able to anticipate, in advance, your response to the anti-TNF.

The researchers in the article have mentioned the medication 'Remicade' specifically and that patients with a low BMI (lower percentage of fat cells than a high BMI score) prior to starting the Remicade showed a much better response to the therapy, after therapy was started and throughout the Remicade dosages as shown to the researchers by these patients exhibiting increased physical abilities and physical functioning. Certainly, one cannot extrapolate these findings outside of the researchers parameters. My biggest question is: what if this opens the door to specific amounts of anti-TNF medications prescribed and allows our rheumatology physicians to choose the dosing intervals as well. For example, one a week, every two weeks, every ten days, etc... It would be more difficult for insurance companies to deny your Rheumatologist's written prescription for dosing amounts and intervals between the next dose if this information was backed up by evidence-based research and practice. I know we are far from that but this is a very interesting article. Many thanks to the researchers for helping us!!

Personally, I would like to be on Humira once every ten days as the helpfulness of this med wore off before the industry standard of 'every two weeks'. Therefore, my insurance company denied my rheumy's request which initiated a change in therapy for me. I switched to Cimzia on the day this request was denied. I feel the insurance company would have a difficult time denying this request if evidence-based practice existed.

Thank you,
TheWino

Reference:

Swift, D. (2016). Study: Extend TNFi Evaluation Period in AS to Six Months. [/i]
MedPage Today[i]
. Retrieved from, http://www.medpagetoday.com/Rheumatology/
Arthritis/56490 on 3/11/2016.


Cimzia, Methotrexate SQ, Sulfasalazine, Prednisone

--Count all your blessings and remember your dreams. J. Buffett
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273606 03/14/16 07:09 PM
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"I think so too. I think it is more of because they(insurance) do not want to change the medications often, as these are very costly. They want to shift the burden on patient to completely exhaust the possibility of medication getting into action at longer periods."

I'm not so sure that is right. Insurance companies would prefer patients to cycle through a class of expensive medications that will in the end may not provide benefits for the patient more quickly.This article suggests prolonging the treatment.


Early 30's male, HLA Negative, AS diagnosed Feb. 2016, Humira.
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273694 03/22/16 04:08 AM
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ok. makes sense.


Male, early 30s. AS diagnosed Sep 2015. HLAB27+
Current medicines: Omeprazole, Vit D3, Celecoxib(1 tab)/Zorvolex(2 tabs)(alternatimg between these two every week), Pyridoxine, Isoniazid, MTX(3 tab) every wednesday, on humira every two weeks since Dec 2015, Weekly Humira since June 18th 2016
On cosentyx 300mg a month since Dec '16
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273695 03/22/16 04:15 AM
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Hi Obrienk,

So, do you think I should try switching my medicine before 6 month period? I am feeling like very frustrated with its benefits. I am no longer in crazy pain, but I feel trapped. Cannot go anywhere, if I do go, I want to sit somewhere, not just anywhere but only my chair, which makes me comfortable). I wish I had better words to explain what I am going through.I am on humira since Dec 2nd last year. It will be 4 months by the time I will get approval(if I get approval by March 31).I have the supply for next month, so will get it going till April 15th).4.5 months. I am thinking secukinumab or Enbrel(have read great reviews about Enbrel and that many people are on it, also I think it is given by body mass ratio which makes it more effective, is this correct?)

Thanks,
Shippingnews

Last edited by Shippingnews; 03/22/16 04:17 AM.

Male, early 30s. AS diagnosed Sep 2015. HLAB27+
Current medicines: Omeprazole, Vit D3, Celecoxib(1 tab)/Zorvolex(2 tabs)(alternatimg between these two every week), Pyridoxine, Isoniazid, MTX(3 tab) every wednesday, on humira every two weeks since Dec 2015, Weekly Humira since June 18th 2016
On cosentyx 300mg a month since Dec '16
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273697 03/22/16 05:23 AM
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Originally Posted By: Shippingnews
Hi Obrienk,

So, do you think I should try switching my medicine before 6 month period? I am feeling like very frustrated with its benefits. I am no longer in crazy pain, but I feel trapped. Cannot go anywhere, if I do go, I want to sit somewhere, not just anywhere but only my chair, which makes me comfortable). I wish I had better words to explain what I am going through.I am on humira since Dec 2nd last year. It will be 4 months by the time I will get approval(if I get approval by March 31).I have the supply for next month, so will get it going till April 15th).4.5 months. I am thinking secukinumab or Enbrel(have read great reviews about Enbrel and that many people are on it, also I think it is given by body mass ratio which makes it more effective, is this correct?)

Thanks,
Shippingnews


I can't say. Personally I've only been on Humira for 3 weeks. I've definitely felt some benefits. I've also started what is as close as possible to a no-starch diet for myself around the same time. I can definitely say the combination of these two things have already offered significant benefits. My neck pain is almost gone, and my lower back pain is down to a more tolerable level. I'd say talk to your rheumatologist. If you haven't received much benefit 4 months in, that might be sufficient to switch, but only a specialist can tell you that.


Early 30's male, HLA Negative, AS diagnosed Feb. 2016, Humira.
Re: Study: Extend TNFi Evaluation Period in AS to 6 mo
Shippingnews #273698 03/22/16 05:48 AM
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if you do not mind me asking, do you have fusion in your spine?


Male, early 30s. AS diagnosed Sep 2015. HLAB27+
Current medicines: Omeprazole, Vit D3, Celecoxib(1 tab)/Zorvolex(2 tabs)(alternatimg between these two every week), Pyridoxine, Isoniazid, MTX(3 tab) every wednesday, on humira every two weeks since Dec 2015, Weekly Humira since June 18th 2016
On cosentyx 300mg a month since Dec '16
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