You specifically mentioned those for whom Cosentyx was working. I'll answer anyway, even though I stopped taking it due to side-effects. I could tell it was working by around the 4th loading dose. At the same time, the side-effects hit 24 hours after the first dose, almost exactly (diarrhea). I ended up stopping the med after the 4th month due to, ironically, constipation. After beginning with diarrhea that lasted a couple of days, starting 24 hrs after my dose, it gradually changed from diarrhea to constipation as the weeks went by. When I mentioned it to the rheumy, he thought it was a little preposterous, but humored me and said I could stop it for 3 months and see what happened. I was convinced it was the med, but waited out the 3 months, hoping to be vindicated. All my PsA symptoms came roaring back, proving it had been working. And the constipation went away gradually, proving it was the med causing those symptoms. It really bothered my gut, but many people do well on it. Hope it starts feeling like it's working soon. Don't fret too quickly. Good luck!
Cimzia is my miracle drug.
Took it for 2.5 yrs and had to stop due to a case of pneumonia that led me down a path of testing that dragged on way too long. Then I had a bad foot fracture that took a long time to heal. Now I'm back on Cimzia and it's beginning to kick in nicely.