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Ketamine infusions
#281452 09/20/18 03:37 PM
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RachelK Offline OP
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Anyone tried ketamine infusions for AS pain?


POTS (dx 2004), AS (dx 3/2016), hEDS (4/2016) and other stuff. HLA B27+ with family history of AS. Enbrel since 6/2016. Indomethacin 2016-2019 (d/c'd in 2019 after ulcer perforated my stomach).
Re: Ketamine infusions
RachelK #281455 09/20/18 11:09 PM
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Ketamine is typically used to make a patient less responsive (anesthesia) and is used to perform procedures which normally would be painful especially in an ER setting. It is a very powerful drug and should be used only with the supervision of trained personnel. That said, there may be useful other uses for depression, pain and sedation. The most important consideration is other medications which are currently being used by the patient as these may potentiate Ketamine.


Diagnosed AS 2001.Remicade 2002 - 5mg/kg every 7 weeks.
Right Eye Trabeculectomy/lens replacement 2006 > DSEK Cornea Transplant 2009.
>Ahmed Shunt 2016 >DSEK Cornea Transplant 2016.
Supra Ventricular Tachycardia. Radio Frequency Ablation 2008.
Cardiac Stent to RCA 9/2020

ICU RN - Seattle, WA
~Grasp The Challenge and Succeed~
Re: Ketamine infusions
WhiteCell #281456 09/20/18 11:55 PM
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Yes, indeed, WhiteCell. It's a recent newcomer of a treatment modality for a different dx of mine, but I'm wondering if anyone has had success with it to treat AS pain.


POTS (dx 2004), AS (dx 3/2016), hEDS (4/2016) and other stuff. HLA B27+ with family history of AS. Enbrel since 6/2016. Indomethacin 2016-2019 (d/c'd in 2019 after ulcer perforated my stomach).
Re: Ketamine infusions
RachelK #281464 09/21/18 06:56 PM
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Thank you RachelK for the question and to WhiteCell for the thoughtful response. I'm always learning from others regarding SpA. Using the search feature on this site, i see that the topic has come up before, there was a nice info link on that thread.


AS, U C, Iritis, migraines. HLA-B27neg. Yoga (instructor) & spin. No meds at this time. Dx 1989. SAA member/donor since 1993. All my posts are personal opinion/feelings and do not represent the SAA. Help find a cure & support others by donating to the SAA.
Re: Ketamine infusions
RAHMBA #281466 09/21/18 07:59 PM
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Thanks, Rahmba.
Hmmmm, I couldn't find much on previous threads. Is it possible to provide the link (or another way to find it)? Thanks so much!


POTS (dx 2004), AS (dx 3/2016), hEDS (4/2016) and other stuff. HLA B27+ with family history of AS. Enbrel since 6/2016. Indomethacin 2016-2019 (d/c'd in 2019 after ulcer perforated my stomach).
Re: Ketamine infusions
RachelK #281468 09/21/18 09:30 PM
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I couldn't find anything on Ketamine infusions either. Lots of threads referring to compounded creams that include ketamine, and one long thread that started out talking about using a ketamine-induced coma to make the brain "reset" itself but then went in several directions as it progressed.

I've always found the search feature a bit frustrating, especially the fact that it only allows you to search 3 years at a time.


Ginny - 58 year old female
Dx with USpA in March 2013; changed to AS in July 2015
Iritis and Scleritis, both currently in remission
unicompartmental knee replacements: right-June 2014, left-Aug 2018
MTX, Humira, Cyclobenzaprine, plus Celebrex as needed
Supplements: Folic Acid, Vitamin A, Vitamin D, Calcium, Fish Oil, Culturelle probiotic, Melatonin (as needed)
Re: Ketamine infusions
RachelK #281469 09/21/18 10:25 PM
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In the studies I've read the results are not better than placebo effects. This citation below argues from a pain control standpoint and suggests more research in needed.

https://www.ajmc.com/newsroom/pain-...ing-ketamine-to-treat-acute-chronic-pain

Bear in mind that anesthesia drugs, Fentanyl Ketamine Propafol decrease one's ability to PERCEIVE pain however the pain still exists. In practice when pain continues the patient is given more drug However, these are powerful sedation and hypnotic medications. They are unlike morphine, hydromorphone, and others contained in Norco, Toradol and others including acetaminophen, ibuprofen which target key pathways to actually relieve the pain itself by mitigating the receptor sites.

Respiratory depression can occur with any of these medications or combination of them. From my reading Ketamine is not a well researched drug for pain control. In practice, we use Ketamine to quickly " medically stun" the patient so that we can get them under control or set a out of joint bone. The effects are dramatic, rapid and must be tightly monitored.

That said, finding drugs which actually relieve pain and/or treatments which are adjuvant therapies are worth pursuing.

Last edited by WhiteCell; 09/21/18 10:27 PM.

Diagnosed AS 2001.Remicade 2002 - 5mg/kg every 7 weeks.
Right Eye Trabeculectomy/lens replacement 2006 > DSEK Cornea Transplant 2009.
>Ahmed Shunt 2016 >DSEK Cornea Transplant 2016.
Supra Ventricular Tachycardia. Radio Frequency Ablation 2008.
Cardiac Stent to RCA 9/2020

ICU RN - Seattle, WA
~Grasp The Challenge and Succeed~
Re: Ketamine infusions
RachelK #281471 09/21/18 11:41 PM
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Originally Posted by RachelK
Anyone tried ketamine infusions for AS pain?


I bet it works great for the pain. I doubt it does anything to control the disease.



Re: Ketamine infusions
RachelK #281498 09/25/18 12:15 AM
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I've considered them but never tried them. I have tried a ketamine nasal spray. That helped with pain. It, of course, does not do anything for inflammation - it's just for pain control. In addition, I'm on an NSAID and biologic and DMARD.

Re: Ketamine infusions
RachelK #281500 09/25/18 04:06 PM
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Yeah, exactly. It won't do anything for disease progression of AS or inflammation; but maybe for chronic pain (i.e. "just" the symptom of pain). I'd love to get off my NSAID, or at least cut back. I'll report back if/when I try it. It's available and covered where I am for another dx I have. Thanks All!


POTS (dx 2004), AS (dx 3/2016), hEDS (4/2016) and other stuff. HLA B27+ with family history of AS. Enbrel since 6/2016. Indomethacin 2016-2019 (d/c'd in 2019 after ulcer perforated my stomach).
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