So, some updates that I think are interesting. I have been researching a bit more and have come across a number of different things (one relatively well known): Peony Flower extract, Thunder God Vine, Boswellia (AKBA,) Jatrophone (from "yagua rova," a Paraguayan remedy,) and possibly Wnt pathway inhibtors (like Harmine, found in ayahuasca brews, and peganum harmala seeds [also known as Syrian Rue].)
It appears that the compounds in the Peony Flower can calm the immune system, so this is a different approach to the standard NF-kB and TNF-alpha inhibition. While this does have analgesic effects by inhibiting these signaling pathways, it also has immunoregulatory effects. LinkLink 2
(The characteristics section)
Thunder God Vine has strong immunoregulatory effects, as well as some other effects that may be potentially concerning to some (such as anti-fertility, however, it is reversed upon cessation of taking it.) Another concern is that it is toxic to the liver. However, this can be countered by taking it with either curcumin or having it in a "licorice processed form." See the links belowLinkLink 2Link 3
Boswellia has been used to protect cartilage and has been used in clinical trials for AS. It is a 5-lipoxygenase inhibitor and a glycoprotein inhibitor (similar to baicalein in skullcap, which is also a 5-lipoxygenase inhibitor and glycoprotein inhibitor [aka P-gp inhibitors.] Note: P-gp inhibitors reduce the body's ability to remove compounds from the cell, so it can potentiate (or make stronger) the effects of other drugs/compounds.LinkLink 2Link 3
Jatrophone B has a significant ability to reduce lesions and damage in the intestines. This may be particularly helpful in alleviating inflammation in the intestines for those with HLA-B27 related issues, as well as a few members I know who have had their systems ravaged by multiple infections here on the forums.Link
The Wnt pathway seems to be linked to bone formation in this study. As mentioned above, Harmine (do a quick google search) inhibits the Wnt pathway. Harmine/Harmaline is found in Peganum Harmala seeds and is usually used as an alternative (a harsher one due to the harmaline being a little more sedative) to the Ayahuasca vine (banisteriopsis caapi.) These are used as MAOI's to inhibit the breakdown of DMT in another substance, usually mimosa hostilis, to keep the DMT in the system for longer and potentiate the trip. DMT is also a strong pain reliever but that is beside the point of this post. It turns out that bone formation in AS could possibly be inhibited by taking the MAOI harmine. This could stave off the bone destruction that occurs, though would have no effect on the inflammation, at least directly.:Link
I hope this information helps and can provide a healthy alternative to someone willing to try. Once again, take all of these statements with a grain of salt and do your own research before trying anything. Start low dose if you do decide to try and work your way up.
P.S. I am currently trying peony and Boswellia. Boswellia gave me the best sleep score I've ever received in my sleep tracking app. I consistently have low sleep scores around 60%, however, on my first night taking it I received a sleep score of 92%. In my entire 6 years of using this app, I have never scored that...ever! Then I stayed up too late the next night, and went to bed late and for a shorter period and received 83%. This is very very interesting to me. More updates in the future.
I am also looking into getting stem cell treatments as I have had some flares related to dietary things I had tried and an unfortunate accident with an antimicrobial regimen I ran while also trying some other compounds. Clearing my gut with antimicrobials made my intestines a little more "leaky" and I had a massive reaction to another compound I normally tolerate just fine. I was in excruciating pain and unable to move for approximately 10 hours. While these compounds help, they can never stop something like this from happening. Stem cells are the big guns that can rebalance the immune system and bring more T-reg cells.
That's all for now folks!