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Immunoglobulin #283266 06/16/19 11:21 PM
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Drenha Offline OP
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Hi all - I just went in for my blood work and found that my new rheumatologist added a series of immunoglobulin tests that I haven't had before. I'll ask my doctor about this when I next see her, but I'm curious if anyone here knows why these tests might be done? Is there a link between immunoglobulin and AS? A quick Google search didn't turn anything up...

Re: Immunoglobulin [Re: Drenha] #283268 06/17/19 02:13 PM
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Winston Offline
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There is a link, and researchers have been looking to immunoglobulin levels in recent years as a better means (than other blood tests, e.g., ESR, CRP) for diagnosing AS. See https://ankylosingspondylitisnews.com/2018/01/23/sugar-molecules-igg-antibody-biomarkers/ and https://ard.bmj.com/content/78/5/705 and https://www.frontiersin.org/articles/10.3389/fimmu.2017.00476/full

If your new rheumatologist is right out of training or affiliated with a research facility, he/she is more likely to be familiar with this new research and use these tests, I think.

Re: Immunoglobulin [Re: Drenha] #283351 07/08/19 02:06 PM
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Tacitus Offline
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Hello, Drenha:

Many years ago, Professor Alan Ebringer of Kings College London discovered that a certain immunoglobulin--IgA-Kp--was responsible for AS, or rather the active agent provocateur. Some AS patients develop a secondary condition due to the proliferation of immunoglobulin: Berger's disease in particular but also other forms of what might be termed "amyloidosis."

The current methods used in measuring serum Ig (IgM, IgA, plus IgG) cannot yet identify the reason these immune components proliferated. A more accurate test would show that these are highly increased within our lymph, produced in response to the presence of the Klebsiella pneumoniae (-Kp) bacterium in our gut (microbiome). This bacterium blooms (population explosion) in the presence of dietary starch.

In this paper (.pdf) figure 1 shows a scatter plot of serum Ig in a large group of patients with active AS, Crohn's, and UC versus control groups.

HEALTH,
John

Last edited by Tacitus; 07/08/19 02:12 PM. Reason: clarify Ig issues

Nota Bene: I am not a medical doctor, and my views do not represent the opinions of the SAA
AS Resources
My Long, Boring AS Story
Professor Alan Ebringer Diet and AS


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