I have the joy of being diagnosed with MS, Crohn's, and AS, but only the AS really bothers me (I think the other two dx were misdiagnosed AS), Anyway, I was frightened into trying biologics for MS when first diagnosed. Rebif and Copaxone injections both made me feel like I had the flu all the time and gave me hives so I switched to Gilenya. This biologic costs $65,000/year and makes me susceptible to every bug that goes around. I haven't had any MS relapses so my Dr says it's working, but I think I really don't have MS. I've chosen to wean off the Gilenya (which they say often causes a horrible relapse when going off, we'll see).
My rheumy is recommending starting Cosentyx or Taltz (anti-TNF blockers can cause MS relapses) but I think I'm going to try LDN and diet. I think that unless I'm desperate and really suffering biologics are just too scary for me. I've had really good luck so far with low/no starch diet, probiotics, and exercise - pain is mostly gone and manageable right now.
I'll be keeping an eye out here too for advice because I may be trying Cosentyx . . . and again, thanks to this forum is how I even heard of the no/low starch diet that has helped me so much. I know it's not for everyone but so far so good (and I lost that extra 20 lbs in a couple months without even trying :-)