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COVID vaccines and TNF inhibitors
#284911 12/13/21 11:31 PM
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I just read this today and it’s a bit disheartening. The study is very small but the takeaway is to get your third dose (and a 4th if eligible 6 months after that)

https://medicalxpress.com/news/2021-11-covid-vaccine-elicits-weak-antibody.html

Quote
People who received two doses of the Pfizer COVID-19 vaccine while on TNF inhibitors—a class of immunosuppressants used to treat rheumatoid arthritis and other autoimmune conditions—generated less powerful and shorter-lived antibodies against the virus that causes COVID-19 than healthy people and those on other kinds of immunosuppressants, according to a study by researchers at Washington University School of Medicine in St. Louis. The scientists found this was especially apparent regarding the virus's delta variant.

The good news is that a third vaccine dose drove antibody levels back up, but the researchers don't yet know how long the levels will stay high. The findings, available online in Med, a Cell Press journal, suggest that people taking TNF inhibitors face a particularly high risk of breakthrough infections and would benefit most from a third dose.


46, diagnosed with AS in early 2005 and on TNF-blockers since then: They have been miracle drugs for me. On Enbrel from spring 2005 to Nov 2008. On Humira from Nov 2008 to present. Baclofen and OTC anti-inflammatories as needed.

"You must be the change you wish to see in the world." --Gandhi
Re: COVID vaccines and TNF inhibitors
Mary Beth #284912 12/13/21 11:57 PM
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TY for sharing. really interesting. agree, could be important to get the booster. only 3% had AS in this study. I suspect there were too few AS people in the study (2) to draw conclusions for just people with AS. The global COVID study for spondylitis did not show higher susceptibility or more severe outcomes for C19 than the general population, for using TNFs. it's a different type of study. best to be safe.


AS, U C, Iritis, migraines. HLA-B27neg. Yoga (instructor) & spin. No meds at this time. Dx 1989. SAA member/donor since 1993. All my posts are personal opinion/feelings and do not represent the SAA. Help find a cure & support others by donating to the SAA.
Re: COVID vaccines and TNF inhibitors
Mary Beth #284952 02/20/22 03:50 PM
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interesting as I am on remicade, got the J&J vaccine (not boosted, had covid and got the micronalantibodies), and have had no abnormal decrease in my immunity.
I will be getting another blood draw to see where natural and vaccine antibodies are. I'm in a study that does a blood draw every 3 months to see where antibodies are.
I wonder if this is specific to the mRNA vaccines.


Carrie
Small business owner, 53 / mother of 5, Fort Worth, Texas
Remicade, Seroquel, Folic Acid, MTX, gabapentin
Undifferented spondylopathy HLA-B27+ (onset 2007- DXed 2008) with associated uveitis, psoriasis
EPI and IBS - gastritis due to NSAIDs
Right Hip replacement 2017 with subsequent 4" heterotopic ossification (removed 2019)
Re: COVID vaccines and TNF inhibitors
Mary Beth #284953 02/26/22 03:29 PM
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I just got my 3rd blood draw results and my natural antibodies are still quite high almost 4 months out of having moderately severe covid. My J&J antibodies are still super boosted from the micronal antibodies and it is not recommended for me to get a booster of any kind at this time.


Carrie
Small business owner, 53 / mother of 5, Fort Worth, Texas
Remicade, Seroquel, Folic Acid, MTX, gabapentin
Undifferented spondylopathy HLA-B27+ (onset 2007- DXed 2008) with associated uveitis, psoriasis
EPI and IBS - gastritis due to NSAIDs
Right Hip replacement 2017 with subsequent 4" heterotopic ossification (removed 2019)

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