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Spondylitis Association of America Forums General Discussion General Message Board for Ankylosing Spondylitis and Related Diseases Do TNF-a drugs prevent Alzheimer's?

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Do TNF-a drugs prevent Alzheimer's? #283205 06/05/19 02:47 PM
Joined: Jun 2016 Posts: 655 Likes: 3 W Winston OP Registered Visitor
OP Winston Registered Visitor W Joined: Jun 2016 Posts: 655 Likes: 3	Interesting story out today about Pfizer's decision not to investigate Enbrel's potential as a treatment for Alzheimer's: https://www.washingtonpost.com/busi...noredirect=on&utm_term=.965a91d0094e Worth reading for its insight into how drug companies make decisions regarding research into possible new uses for old drugs and for its discussion (deep in the article) of how systemic inflammation might contribute to dementia.

Re: Do TNF-a drugs prevent Alzheimer's? Winston #283208 06/05/19 06:18 PM
Joined: Jun 2012 Posts: 745 Likes: 6 Los Angeles, CA RAHMBA Registered Visitor
RAHMBA Registered Visitor Joined: Jun 2012 Posts: 745 Likes: 6 Los Angeles, CA	Thank you for sharing this. Really interesting. AS, U C, Iritis, migraines. HLA-B27neg. Yoga (instructor) & spin. No meds at this time. Dx 1989. SAA member/donor since 1993. All my posts are personal opinion/feelings and do not represent the SAA. Help find a cure & support others by donating to the SAA.

Re: Do TNF-a drugs prevent Alzheimer's? Winston #283209 06/05/19 06:23 PM
Joined: Mar 2013 Posts: 2,177 MS S SouthernMoss Registered Visitor
SouthernMoss Registered Visitor S Joined: Mar 2013 Posts: 2,177 MS	Thanks Winston. A very interesting read. Ginny - 58 year old female Dx with USpA in March 2013; changed to AS in July 2015 Iritis and Scleritis, both currently in remission unicompartmental knee replacements: right-June 2014, left-Aug 2018 MTX, Humira, Cyclobenzaprine, plus Celebrex as needed Supplements: Folic Acid, Vitamin A, Vitamin D, Calcium, Fish Oil, Culturelle probiotic, Melatonin (as needed)

Re: Do TNF-a drugs prevent Alzheimer's? Winston #285079 02/09/23 08:13 PM
Joined: Jun 2012 Posts: 745 Likes: 6 Los Angeles, CA RAHMBA Registered Visitor
RAHMBA Registered Visitor Joined: Jun 2012 Posts: 745 Likes: 6 Los Angeles, CA	Study out of Israel published in August 2022. https://doi.org/10.1016/j.phrs.2022.106325 regarding increased risk of alzheimer's in AS and the benefit of TNF for this risk. I haven't see it referenced in other AS studies. AS, U C, Iritis, migraines. HLA-B27neg. Yoga (instructor) & spin. No meds at this time. Dx 1989. SAA member/donor since 1993. All my posts are personal opinion/feelings and do not represent the SAA. Help find a cure & support others by donating to the SAA.

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