I have been on and off almost every biologic. Yes, you can go back on it after a few years. Your body forgets how it works. I have jumped back on Enbrel twice. The best thing to do is go through each one Remicade, Simponi, Humara, Enbrel, etc until they all burn out then swing back around and start over. The only one you cannot safely go back on is Remicade. I tried and ended up in the ER. Most people have a bad response to it for some reason going back on it. Some don't.
But yes, it does work.