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If enbrel stopped working, does it work ever again #284222 04/21/20 06:19 PM
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dgopal1 Offline OP
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Hi all
I was diagnosed with AS in 2008. Enbrel worked like a miracle for a decade. I went off it 2 yrs ago when it became ineffective and switched to cosentyx.
It worked for a while but Im starting to feel pain creep up again slowly.

I wanted to here if it is worth going back to retrying enbrel again before trying other anti tnfs or IL17s?

Regards
Divya

Re: If enbrel stopped working, does it work ever again [Re: dgopal1] #284228 04/24/20 01:28 AM
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Tacitus Offline
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Hello, Divya:

It is of course worth a try, but I doubt that, once the immune system is trained to produce antibodies to something, it would "forget." The biologic agents do not address the root cause of AS and should only be an adjunct therapy.

HEALTH,
John


Nota Bene: I am not a medical doctor, and my views do not represent the opinions of the SAA
AS Resources
My Long, Boring AS Story
Professor Alan Ebringer Diet and AS

Re: If enbrel stopped working, does it work ever again [Re: dgopal1] #284229 04/24/20 02:04 PM
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Winston Offline
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Your rheumatologist is probably the best person to ask, but I'll note that Enbrel doesn't tend to trigger the same antibody response that the monoclonal antibody drugs like Humira do.

Re: If enbrel stopped working, does it work ever again [Re: Winston] #284230 04/24/20 06:54 PM
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achala Online
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Originally Posted by Winston
I'll note that Enbrel doesn't tend to trigger the same antibody response that the monoclonal antibody drugs like Humira do.


could we delve deeper into this? personal interests. is it the dna splicing demand reconfirmation (signaling) from T to B cell that is different? Or the follicular dendritic cells selection of B cells?
By the way did they make until now smth that signal Fc receptor on B Cell to chill?

Last edited by achala; 04/24/20 06:57 PM.

diagnosed with AS April 2018, starting with cervical pain/stiffness; Aug 2018 enthesitis/bursitis left Achilles
diagnosed with AAU Nov 2017 (7 flares so far)
Eosinophilic Gastritis
Sulfasalazine 3g 08.2018-05.2019 (worked for AAU & peripheral)
Supplements:C/D, omega 3/Probiotic/ Mediterranean NSD/curcumin
swimming/yoga/pilates
Predonisone in case of another AAU flare
Re: If enbrel stopped working, does it work ever again [Re: dgopal1] #284231 04/24/20 11:08 PM
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Winston Offline
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I have no idea.

This study confirms what I said: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407581/

This study tries to answer the question, in very scientific terms, why monoclonal antibody drugs trigger an antidrug antibody response: https://www.frontiersin.org/articles/10.3389/fimmu.2019.02921/full

Enbrel is, of course, a TNF receptor fusion protein, rather than a monoclonal antibody.

Re: If enbrel stopped working, does it work ever again [Re: dgopal1] #284326 06/26/20 12:45 AM
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I have been on and off almost every biologic. Yes, you can go back on it after a few years. Your body forgets how it works. I have jumped back on Enbrel twice. The best thing to do is go through each one Remicade, Simponi, Humara, Enbrel, etc until they all burn out then swing back around and start over. The only one you cannot safely go back on is Remicade. I tried and ended up in the ER. Most people have a bad response to it for some reason going back on it. Some don't.

But yes, it does work.


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