I started Enbrel in late October, 2008.
Sometimes I get the red, itchy lumps/bumps at the injection sites but not always. (I self-inject with syringes at home once a week.)
The Enbrel gives/gave me severe headaches, which in the beginning were starting within minutes of the injection and lasting 4 to 5 days. But I was willing to put up with them, because I am suffering from severe headaches already anyway, and I want to give the Enbrel a chance to work. Upon talking to my rheum., I was advised that for patients prone to headaches already, this side effect is more pronounced/more severe/more risk of happening. They advise patients to switch the injection to right before bedtime (so you go to sleep right away hopefully) and to take Tylenol or Benadryl OTC before the injection if not contraindicated. Also, they said for most patients, the length of time and strength of the headaches usually decreases with time. This has been the case with me.
I still get headaches with the injections, but they are not as bad and are down to a few hours usually. (Still have the other stupid headaches. Rats!)
The biggest problem I've actually had is getting the needle to break through my skin, and then when it is through initially to continue pushing all the way in... And believe me, I am very used to giving shots. I am diabetic, insulin dependent, and give myself at least 5 insulin shots per day. While going through fertility treatments, I did all those shots -- and for those who think Enbrel has a burn... Let me tell you, I can't even feel the Enbrel compared to that (*$^((#@@)&^%@$. AND I used to be a certified Paramedic and Assistant Chief of our local ambulance service. So lots of shots given and taken. But these Enbrel needles just don't want to punch through my skin. I don't know if it is because of the latex cap...
As for giving the injection: The rheum. advised letting the Enbrel warm up for 15 to 30 minutes by taking it out of the fridge before giving it as some patients did report a burn or "bite". It doesn't bother me in this way -- I do take it out ahead of time as advised.