Took 4 months for me. Hardest part was trying to figure out if I felt better or not. I had to come off it for a month and that's when I realized it was surely doing something. Going to start Remicade and this time I'm going to keep a diary so I can look back at my pain log. Otherwise it kind of starts blending together over the months and unless you're one of the people with miraculous light switch type result it can be tough to remember the progress if it's gradual. Could be working more than you think.