I have been on Enbrel for 6+ years. Take 2 25mg injections per week. Never lost weight because of the drug. I am though going to talk to Dr about using something different because I feel the Enbrel is not as effective anymore. Cannot take NSAIDs anymore because of the effects on liver and kidneys. It is disheartening to have pain and fatigue everyday. I do get steriod shots every so often. Dr. gave me Tramadol for pain too but I find it makes me nauseated.