Thank you all! It is so nice to be able to hear from people who have been where I am now. I think I will run it by my doctor and if they don't think there is a reason to give up just yet, I'll stick it out a bit longer. The sinus stuff worries me. I've always had sinus problems. Remicade was actually a great "allergy" med. I had almost no sinus issues while on it, apart from the nose issues caused by methotrexate (sores and bleeding). So, it is doubly bad to lose that unexpected benefit and go straight to swollen sinus misery! To top it off, I'm at a juncture in my career where I especially need energy and a clear head, and, well, I seem to have neither!