Enbrel worked great for me for only a few years and then stopped working rather suddenly. Perhaps not coincidentally, I had noticed stronger and stronger injection site reactions in the months before it stopped working, to the point that the injections sites from four or five weeks ago would all puff up when I'd do a new shot.
I switched to Humira and had the same strong success I originally had with Enbrel. My sed rate tracks closely with disease activity and it has been normal for years. I think I have the year I started in my signature line.
Question for you: were you fused before taking a biologic and do you think it has slowed your progression?