I'm currently on my fourth (4th) biologic because my body is apparently just too clever to fall for all those other attempts...
Each round is it's own unique experience, but I have been fortunate to find better results with each switch. My path has included Enbrel, Humira, Remicade and now Cosentyx. The longest I've ever been able to stay on any one option is about a year, some a little less, some a little more; in the end, my antibodies solve the puzzle and we try again. I'm so thankful that there are many more options still to try, so I always look forward to the change hoping that I'll find my "magic bullet".
HLA-B27 neg, MTX, Folic Acid, Belbuca, Cosentyx (failed Enbrel, Remicade, Humira). Diclofenac caused kidney failure, Hard breakup with Norco.